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(NRP-87) DNA gyrase bond

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DNA gyrase bond
Steve Hearnshaw, Tony Maxwell and Dave Lawson
NRP-87

DNA gyrase is an essential bacterial enzyme that introduces negative supercoils into DNA. It employs a complex DNA strand passage mechanism that involves the sequential opening and closing of three protein interfaces. Simocyclinone D8, a Streptomyces-derived antibiotic, is a potent inhibitor of DNA gyrase. Scientists at the John Innes Centre on the Norwich Research Park have used X-ray crystallography to reveal the mode of action of this antibiotic, whereby it binds across one of these interfaces and locks it in a closed conformation.

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