Novel antibiotic: Coelimycin
Marco Gottelt, University of Groningen
While many actinomycetes are known to produce more than one antibiotic, genome sequencing of these organisms has revealed that they have the potential to make many more. Research carried out at the John Innes Centre on the Norwich Research Park is developing ways to turn on silent gene clusters to yield novel compounds with clinical potential. In a collaboration with the University of Groningen, manipulation of one such silent gene cluster in S. coelicolor resulted in the production of a novel yellow-pigmented antibiotic, coelimycin, shown here in a water droplet on top of a lawn of the sporulating organism.