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(NRP-237) Sequence alignment of bacterial peptides

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Sequence alignment of bacterial peptides
Andrew Truman, John Innes Centre

The analysis of genetic data can inform the discovery of new antibiotics made by bacteria. For example, newly sequenced pathways that are similar, but not identical, to known pathways are likely to produce related antimicrobials. Many antimicrobial natural products are derived from peptides, so genes encoding similar peptides can be identified from new genomes. This figure from the Truman laboratory at the John Innes Centre on the Norwich Research Park shows a sequence alignment of peptides from bacteria isolated from an East Anglian field in comparison to the sequence of the peptide precursor of microcin B17 (MccB17), a potent antibiotic produced by E. coli.

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