Analysis of antibiotic production
Juan Pablo Gomez-Escribano, John Innes Centre
More than three quarters of all compounds used as antibiotics, or that we transform into useful antibiotics, are naturally produced by a group of microbes called actinomycetes. One of these microbes alone, Streptomyces coelicolor, can make five different antibiotics. To analyse and study the production of these compounds at the John Innes Centre on the Norwich Research Park, we use state-of-the-art technologies like HPLC-MS to separate and identify the diversity of chemicals being made. These sample vials have been prepared for analysis, however it is already clear in which vials the yellow-orange antibiotic coelimycin is present!