Strictosidine from periwinkle
Sarah O’Connor and Andrew Davis (JIC)
Strictosidine, from the Madagascan periwinkle (Catharanthus roseus) is an important building block in the development of the chemotherapy drug vinblastine. Researchers at the John Innes Centre on the Norwich Research Park are attempting to elucidate and engineer the pathway that produces this molecule. The biosynthetic production of strictosidine, using yeast as a host system, would enable a much higher yield of this expensive cancer treatment.